Understanding terrestrial carbon metabolism is critical because terrestrial ecosystems play a major role in the global carbon cycle. Furthermore, humans have severely disrupted the carbon cycle in ways that will alter the climate system and directly affect terrestrial metabolism. Changes in terrestrial metabolism may well be as important an indicator of global change as the changing temperature signal. Improving our understanding of the carbon cycle at various spatial and temporal scales will require the integration of multiple, complementary and independent methods (...) that are used by different research communities. Tools such as air sampling networks, inverse numerical methods, and satellite data allow us to study the strength and location of the global- and continental-scale carbon sources and sinks. Bottom-up studies provide estimates of carbon fluxes at finer spatial scales and examine the mechanisms that control fluxes at the ecosystem, landscape, and regional scales. Bottom-up approaches include comparative and process studies that provide the necessary mechanistic information to develop and validate terrestrial biospheric models. An iteration and reiteration of top-down and bottom-up approaches will be necessary to help constrain measurements at various scales. We propose a major international effort to coordinate and lead research programs of global scope of the carbon cycle. (shrink)

A crisis continues to brew within the pharmaceutical research and development (R&D) enterprise: productivity continues declining as costs rise, despite ongoing, often dramatic scientific and technical advances. To reverse this trend, we offer various suggestions for both the expansion and broader adoption of modeling and simulation (M&S) methods. We suggest strategies and scenarios intended to enable new M&S use cases that directly engage R&D knowledge generation and build actionable mechanistic insight, thereby opening the door to enhanced productivity. What M&S requirements (...) must be satisfied to access and open the door, and begin reversing the productivity decline? Can current methods and tools fulfill the requirements, or are new methods necessary? We draw on the relevant, recent literature to provide and explore answers. In so doing, we identify essential, key roles for agent-based and other methods. We assemble a list of requirements necessary for M&S to meet the diverse needs distilled from a collection of research, review, and opinion articles. We argue that to realize its full potential, M&S should be actualized within a larger information technology framework—a dynamic knowledge repository—wherein models of various types execute, evolve, and increase in accuracy over time. We offer some details of the issues that must be addressed for such a repository to accrue the capabilities needed to reverse the productivity decline. (shrink)

The vast network of Drosophila geneticists spawned by Thomas Hunt Morgan's fly room in the early 20th century has justifiably received a significant amount of scholarly attention. However, most accounts of the history of Drosophila genetics focus heavily on the "boss and the boys," rather than the many other laboratory groups which also included large numbers of women. Using demographic information extracted from the Drosophila Information Service directories from 1934 to 1970, we offer a profile of the gendered division (...) of labor within Drosophila genetics in the United States during the middle decades of the 20th century. Our analysis of the gendered division of labor supports a reconsideration of laboratory practices as different forms of work. (shrink)

The existence of consciousness in animals may have been overlooked. Continuity in consciousness between humans and animals is predicted by evolutionary theory. However, there are specific methodological difficulties associated with investigating such a phenomenon: it cannot be directly measured; animals, unlike humans, cannot directly tell us about their conscious experience; experiments which have made comparisons to human consciousness cannot detect consciousness of a different form; application of the law of parsimony in science has traditionally led to the conclusion that it (...) does not exist. (shrink)

Beginning with an overview of Galileo's earliest work on free fall, the paper examines the relationship between experiment and theory in his study of motion in the period immediately before and after 1604. The possible role of experiment is assessed in relation to the manuscript evidence and by means of reconstructed experiments.

The time taken to react voluntarily to a stimulus is far longer than can be accounted for by ordinary processes of nerve conduction and synaptic delay, and varies unpredictably from trial to trial. Though random, the distribution of reaction times usually follows a relatively simple law, which in turn can be explained by the LATER model, in which a decision signal, representing belief in the existence of the target, rises in response to incoming sensory evidence from an initial value to (...) a criterion level at which action is initiated. But the rate of rise fluctuates randomly from trial, to an extent that cannot be explained by sensory noise at the input. These conclusions, confirmed by recording from neurons in the frontal eye fields, suggest that the randomness of reaction time is due to a deliberate, gratuitous, neural process which confers certain biological advantages as well as having implications for general ideas about the nature of ‘free will'. (shrink)

Bernard Nieuwentijt ist in der Mathematikgeschichte bekannt als Kritiker der Leibnizschen Differentialrechnung. Im Gegensatz zu dem, was häufig angenommen wird, war die Kritik an Leibniz' Methode kein Hauptanliegen Nieuwentijts. Das Ziel seines bedeutendsten mathematischen Werks, Analysis infinitorum , war die Systematisierung und logische Deduzierung der ihm bekannten Infinitesimalmethoden, besonders derer von den Engländern wie Barrow, Wallis u. a. Das Werk Leibnizens war ihm anfangs völlig unbekannt. In dem System, das Nieuwentijt selbständig entwarf, rechnete er nicht mit Infinitesimalen höheren Grades: ihre (...) Existenz hielt er für unmöglich. Dies brachte ihn zur Kritik der Leibnizschen Methode, als er später auf dessen Werk stieß. Später aber erkannte er die Unhaltbarkeit seiner Kritik, wie klar wird aus seinem posthumen Werk Gronden van zekerheid . Der Aufsatz gibt überdies zur Fundierung dieser Thesen einen sehr kurzen Überblick über Nieuwentijts mathematische Arbeiten und eine Besprechung neuerer Interpretationen. (shrink)

Summary One aim of this paper is to provide an assessment of the recent attempts to interpret the development of Galileo's theory of motion in the late Paduan period 1604?1610. In addition to this a new interpretation of this process of development is advanced. This interpretation is the first that proves able to provide a full account of all the features on folio 152r of volume 72 of the Galilean manuscripts which has been claimed to be of crucial significance. The (...) major feature of the interpretation is that it is the first to account for the relationship between Galileo's theoretical and experimental work in the period 1604?1610. (shrink)

Recent study of Galileo's surviving manuscript notes on motion has revealed that by 1609 he had developed the major part of his theory of projectile motion. During the period of these theoretical advances Galileo was engaged in important related experimental investigations; this has become clear from the study of folios 114r and 116v of the manuscript on motion. This paper provides an interpretation of a manuscript not previously discussed—folio 81r. The analysis provided indicates that it is evidence of an important (...) early experiment of the series in which Galileo studied the projectile trajectory. The reconstruction of the experiment concerned reveals relationships with the enquiries suggested by folio 114r and 116v and indicates that Galileo examined the form of projectile trajectories with some care. (shrink)

Plato was born around 2,500 years ago. He lived in a small city-state in Greece and busied himself with the problems of his fellow Greeks, a people living in scattered cities around the Mediterranean and the Black Sea. In all he tried to do for the Greeks he failed. Why, then, should people in the modern world bother to read what he had to say? Does it make sense to go to a Greek thinker for advice on the problems of (...) an age so different from his own? To anyone who has questioned the relevance of Plato to the modern world Richard Crossman’s lively book provides a brilliant reply. The problems facing Plato’s world bear striking parallels to ours today, the author maintains, so who better to turn to than Plato, the most objective and most ruthless observer of the failures of Greek society. Crossman’s engaging text provides both an informed introduction to Greek ideas and an original and controversial view of Plato himself. (shrink)